In vivo BCMA CAR-T phase 1: 15 months of follow-up, one ongoing sCR
Green CAR-T cells attacking a red myeloma cell at right
ENGLISH EDITION · UPDATED WEEKLY
InLight Bio
New biomedical science, read from the primary paper: organoids, disease models, AI drug design, immunology, antibodies, nucleic-acid medicines and precision oncology. Plus China biopharma deals and partnering events, each linked to its source.
36 science briefs13 deal briefs26 events listed
Latest science
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A pIgR bispecific raises cynomolgus BAL exposure 5.5-fold
A bispecific crossing airway epithelial cells and released at the airway surface
Synthetic TCR library: on average only 56% of VDJdb TCRs reproduce their annotated reactivity
Green peptide-MHC complexes binding synthetic TCRs, with one non-reproducing case marked in red
Targeting ZMYND8 increases effector-like exhausted T cells in mice and enhances immunotherapy responses
Green immune cells attacking red tumour cells
TSC2 loss produces astrocyte reactivity in organoids at all 3 time points
Astrocytes in a brain organoid cross-section, with reactive cells in red
Human cortical organoids in apallial mice: grafts make up 91.9% of cortical volume
The green area in a brain cross-section is the transplanted human cortical organoid
Human DPP9 loss causes HSPC depletion through CARD8 pyroptosis
A normal haematopoietic stem cell at left and a pyroptotic, ruptured cell at right
A single inhaled dose of ARO-RAGE lowered BALF sRAGE by 90.2%
Alveoli and droplets at left, with the siRNA cleaving messenger RNA at right
Latest deals & data
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Novartis takes global rights to Abogen's in vivo mRNA T-cell engager ABO2203
$575M upfront; up to ~$7.8B total
GSK buys Chimagen's trispecific T-cell engager for up to $750M
Up to $750M total
Simcere Zaiming licenses CD79a×CD19×CD3 trispecific SIM0660 to Roche
Up to $1.53B total
Upcoming conferences
All events →Oct 23–27, 2026ESMO Congress 2026Madrid, Spain · ScientificNov 2–4, 2026BioCentury-BayHelix China Healthcare Summit (13th)Shanghai, China · PartneringNov 4–8, 2026SITC 2026 Annual MeetingPhoenix, AZ, USA · ScientificNov 5–9, 2026AASLD The Liver Meeting 2026Denver, CO, USA · ScientificNov 6–11, 2026ACR Convergence 2026Orlando, FL, USA · ScientificNov 9–11, 2026BIO-Europe 2026Cologne, Germany · PartneringNov 16–19, 2026Jefferies Global Healthcare Conference (London)London, UK · InvestorDec 1–3, 2026Piper Sandler 38th Annual Healthcare ConferenceNew York, NY, USA · InvestorDec 12–15, 2026ASH Annual Meeting 2026 (68th)New Orleans, LA, USA · Scientific
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